Renier van der Hoorn
We investigate the molecular mechanisms underpinning host manipulation by plant pathogens, with a particular focus on manipulation of Solanaceous plants by bacterial microbes in the plant apoplast (extracellular space). Our research activities also aim to improve molecular pharming of secreted proteins in plants. A key approach for our research is the display of protein activities by activity-based protein profiling (ABPP), a powerful functional proteomics technology that we have pioneered in plants.
We are currently collaborating with Chris Schofield and Jonathan Burton (Department of Chemistry) to synthesise and test an ABPP probes for phytochelatin synthase and cytochrome P450s, and with and Christina Redfield (Department of Biochemistry) to solve the structure of the cystatin-like Epic2B protein, which is a protease inhibitor secreted by the Irish Potato Famine pathogen, Phytophthora infestans.